Venki Ramakrishnan has had a longstanding interest in ribosome structure and function. In 2000, his laboratory determined the atomic structure of the 30S ribosomal subunit and its complexes with ligands and antibiotics. In the last few years, Ramakrishan's lab has published high-resolution structures of functional complexes of the entire ribosome during decoding, peptidyl transfer, translocation and termination. This work has led to insights into how the ribosome "reads" the genetic code, as well as into various aspects of antibiotic function. Since 1999, he has been on the scientific staff of the MRC Laboratory of Molecular Biology in Cambridge.
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